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Targeted Therapiesfor patients with cancer

With deep expertise in chemistry and structure-based drug discovery, Nuvalent is creating precisely targeted therapies for patients with cancer.

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Chemistry at the Core

We design innovative small molecules that precisely inhibit clinically proven kinase targets to solve for the dual challenges of resistance and selectivity.

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Built for Patients

We partner with physician-scientists to identify patient needs and the limitations of existing therapies.

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Driven by Purpose

We are passionate about using our expertise to address the needs of patients with cancer.

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Our clinical trials

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A Phase 1/2 study of zidesamtinib (NVL-520) in patients with advanced ROS1-positive NSCLC and other solid tumors.

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A Phase 1/2 study of neladalkib (NVL-655) in patients with advanced ALK-positive NSCLC and other solid tumors.

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A Phase 3 study of neladalkib (NVL-655) in patients with TKI-naïve ALK-positive NSCLC.

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A Phase 1 study of NVL-330 in patients with advanced HER2-altered NSCLC.

Read the latest news

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  • Oct 13, 2025

    Nuvalent to Present New Preclinical Data for HER2-Selective Inhibitor, NVL-330, at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

  • Sep 24, 2025

    Nuvalent to Participate in the UBS 2025 Virtual Oncology Day

  • Sep 07, 2025

    Nuvalent Presents Pivotal Data from ARROS-1 Clinical Trial of Zidesamtinib for TKI Pre-treated Patients with Advanced ROS1-positive NSCLC at WCLC 2025